BRAF Genetic Test
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| BRAF Genetic Test : - What is a - BRAF - genetic test? A BRAF genetic test uses a sample of tumor tissue, bone marrow, or blood to look for changes in a gene called BRAF. Changes in your genes are also called gene variants or mutations. The test is usually done to look for changes in the BRAF gene that may be involved in cancer. Genes are parts of DNA in your cells that you inherit from your parents. Genes carry information that controls what you look like and how your body works. The BRAF gene provides instructions for making a protein that tells your cells when to grow and divide to make new cells. Certain changes in your BRAF gene may change the gene's instructions and lead to BRAF proteins that are too active. These abnormal BRAF proteins trigger too much cell growth. As a result, cells that have the changed BRAF gene may grow out of control and become cancer. Changed BRAF genes and their proteins are commonly found in melanoma, the most serious form of skin cancer. Changes are also found in several other types of cancer, including colon, thyroid, ovarian, lung, and certain blood cancers. Cancers with changes in the BRAF gene tend to grow more quickly than cancers that don't have this gene change. Knowing whether your cancer has a changed BRAF gene can help your health care provider choose the most effective treatment for you. Changes in your BRAF genes can be acquired or inherited from your parents: - Acquired changes in your BRAF genes develop sometime after you're born. Most changes in BRAF genes are acquired. These changes can happen if your cells make a mistake when they divide to make new cells. Changes can also happen if you're exposed to substances that cause cancer. Acquired changes in genes show up only in certain types of cells. They're usually not in sperm or egg cells, so you can't pass them down to children. - Inherited changes in your genes are changes that you're born with. All the cells in your body have the gene change, including your egg or sperm cells. That means you can pass the change down to your children. Inherited changes in the BRAF gene are very rare, but they can increase your risk of cancer or cause different types of genetic conditions that are present from birth. Other names: BRAF gene mutation analysis, Melanoma, BRAF V600 mutation | |
| Review Date: 07/09/2023 | Updated By: |